In the clinical routine, the renal function is measured in terms of the glomerular filtration rate (GFR). The gold standard for the assessment of the GFR is the inulin clearance at steady state; however, this approach is cumbersome and time consuming. Similar to the whole-body tracer clearance in scintigraphy, functional MRI with the use of gadolinium-based contrast media allows the quantification of the GFR using an approach based on the renal clearance of gadobutrol from the extracellular fluid volume monitored via time-signal curves measured in liver parenchyma. Therefore, contrast-enhanced dynamic MR nephrography may provide the comprehensive evaluation of renal function and vessel morphology within a single examination. This technique seems especially versatile for evaluation of potential kidney donors within a one-stop-shop exaimnation. The MR-based calculation of split renal function and potential urinary drainage obstruction is especially suitable in the evaluation of pediatric patients with urinary tract anomalies.
Artunc F, Rossi C, Boss A. MRI to assess renal structure and function. Curr Opin Nephrol Hypertens. 2011; 20: 669-675.
Artunc F, Yildiz S, Boss A, Frenzel T, Schlemmer HP, Schick F, Risler T, Häring HU, Rossi C. Measurement of glomerular filtration rate using dynamic magnetic resonance imaging in patients with chronic kidney disease. J Nephrol. 2011; 24: 482-489.
Artunc F, Yildiz S, Rossi C, Boss A, Dittmann H, Schlemmer HP, Risler T, Heyne N. Simultaneous evaluation of renal morphology and function in live kidney donors using dynamic magnetic resonance imaging. Nephrol Dial Transplant. 2010; 25: 1986-1991.
Rossi C, Boss A, Artunc F, Yildiz S, Martirosian P, Dittmann H, Claussen CD, Heyne N, Schick F, Schlemmer HP. Comprehensive assessment of renal function and vessel morphology in potential living kidney donors: an MRI-based approach. Invest Radiol. 2009; 44: 705-711. Boss A, Schaefer JF, Martirosian P, Obermayr F, Fuchs J, Claussen CD, Schick F, Schlemmer HP. Dynamic magnetic resonance nephrography and urography of uropathies in children. Rofo. 2007; 179: 832-840.
Boss A, Martirosian P, Schaefer JF, Gehrmann M, Artunc F, Risler T, Oesingmann N, Claussen CD, Schlemmer HP, Schick F. Dynamic magnetic resonance nephrography: is saturation recovery TrueFISP advantageous over saturation recovery TurboFLASH? Invest Radiol. 2007; 42: 256-262.
Boss A, Martirosian P, Gehrmann M, Artunc F, Risler T, Oesingmann N, Claussen CD, Schick F, Küper K, Schlemmer HP. Quantitative assessment of glomerular filtration rate with MR gadolinium slope clearance measurements: a phase I trial. Radiology. 2007; 242: 783-790.
Boss A, Schaefer JF, Martirosian P, Hacker HW, Darge K, Claussen CD, Küper K, Schick F, Schlemmer HP. Contrast-enhanced dynamic MR nephrography using the TurboFLASH navigator-gating technique in children. Eur Radiol. 2006 ; 16:1509-1518.
Department of Radiology
University Hospital of Zürich