Department of Radiology
Imaging Division
University Hopital Zürich

In translational research the development of suitable non-invasive in-vivo imaging techniques bridges the gap between preclinical and clinical investigations. The non-invasive nature of modern imaging strategies can be used to perform longitudinal studies with a lower number of animals; therefore these techniques are indispensable tools for compliance to guidelines for animal welfare in preclinical research ("RRR": reduce, replace, refine). Moreover, modern preclinical imaging technologies provide important additional information that cannot be obtained from conventional ex-vivo techniques (such as immunohistochmeistry).

Our research froup closely cooperates with multiple basic research groups to develop suitable imaging strategies and post-processing tools to answer the individual scientific questions. An example is given below:

In a close research cooperation to the Division of Thoracic Surgery, we developed a dedicated MRI technique for assessment of early ischaemic/reperusion injury after syngeneic lung transplantation in a mouse model. Lung MRI is hampered by two obstacles: (a) low spin density of the pulmonary parenchyma and (b) extremely fast decay of the transverse magnetization due to microscopic magnetic field inhomogeneities caused by tissue-air interfaces in the lung. These effects gets even more pronounced at higher field strength such that conventional MRI techniques (RARE, GRE) fail to detect signal from lung parenchyma. By development of a technique for imaging with ultra-short echo-times, we were able to show that MRI can be applied to visualize and characterize pulmonary infiltration from ischaemic/reperfusion injury at 4.7 Tesla.

» Jungraithmayr W, Chuck N, Frauenfeld T, Weder W, Boss A. MR Imaging by Using Ultra-Short Echo-Time after Syngeneic Lung Transplant in Mice. Radiology (in press)

Research Topics
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Contact Information
Andreas Boss
Department of Radiology
Imaging Division
University Hospital of Zürich
Rämistr. 100
8006 Zürich
Switzerland
Tel.: +41-44-2553677
FAX: +41-44-2554344
Email: andreas.boss@usz.ch