Our research froup closely cooperates with multiple basic research groups to develop suitable imaging strategies and post-processing tools to answer the individual scientific questions. An example is given below:
In a close research cooperation to the Division of Thoracic Surgery, we developed a dedicated MRI technique for assessment of early ischaemic/reperusion injury after syngeneic lung transplantation in a mouse model. Lung MRI is hampered by two obstacles: (a) low spin density of the pulmonary parenchyma and (b) extremely fast decay of the transverse magnetization due to microscopic magnetic field inhomogeneities caused by tissue-air interfaces in the lung. These effects gets even more pronounced at higher field strength such that conventional MRI techniques (RARE, GRE) fail to detect signal from lung parenchyma. By development of a technique for imaging with ultra-short echo-times, we were able to show that MRI can be applied to visualize and characterize pulmonary infiltration from ischaemic/reperfusion injury at 4.7 Tesla.
» Jungraithmayr W, Chuck N, Frauenfeld T, Weder W, Boss A. MR Imaging by Using Ultra-Short Echo-Time after Syngeneic Lung Transplant in Mice. Radiology (in press)
Department of Radiology
University Hospital of Zürich